
SynBioBeta Speaker
Blake Simmons
LBNL
Dir. Bio. Sys & Engg
Blake Simmons is a senior scientific leader at Lawrence Berkeley National Laboratory, where he serves as Director of the Biological Systems & Engineering Division. His work focuses on integrating biology, chemistry, and engineering to enable biomanufacturing and the production of affordable and scalable biofuels and bioproducts. Blake is the Chief Science and Technology Officer of the Joint BioEnergy Institute (JBEI, jbei.org), where he has driven advances in biomass deconstruction and conversion. He is widely recognized for translating fundamental science into scalable technologies and for bridging national-lab innovation with commercialization and deployment and is the co-founder of three startups.
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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