"Reading, writing, and editing DNA were just the prelude. The new frontier is composition—designing entire genomes like symphonies, guided by AI models trained on millions of sequences. In this new paradigm, biology becomes a writable medium where genes, circuits, and chromosomes are arranged with intention rather than discovered by chance. From AI-optimized CRISPR systems and compact editors like TIGR to CRISPR SWAPnDROP and Bridge Recombinases capable of megabase-scale rewrites in human cells, a new toolkit is emerging that treats the genome not as a fragile molecule but as an editable architecture. These molecular instruments bypass the cell’s own repair machinery, offering a level of precision and predictability that brings genome design closer to true composition—a craft as deliberate and creative as writing code or composing music.