Aging is increasingly understood as a gradual loss of biological stability. DNA accumulates damage, protein homeostasis collapses, and cells drift away from youthful identities as regulatory networks lose their balance over time. These changes ripple across tissues and organs, driving many of the diseases associated with aging. Today, new tools in synthetic biology, artificial intelligence, and gene editing are revealing how these systems might be stabilized, repaired, or even reset. Researchers are engineering enhanced DNA repair mechanisms inspired by long-lived species, using AI to map the trajectories of cellular aging and uncover rejuvenating interventions, and developing therapies that restore protein metabolism to protect vulnerable tissues such as the brain. This session explores how scientists are moving beyond simply slowing aging to engineering the biological systems that maintain cellular integrity. By targeting the underlying mechanisms that govern genome stability, proteostasis, and cellular identity, researchers are laying the groundwork for a new generation of longevity therapeutics designed to restore function and resilience across the lifespan.