SynBioBeta Speaker
Fan Yang
Capital O
Partner
Yang Fan is a Partner at Capital O, a frontier technology VC firm, and the author of the influential newsletter "范阳," (Yang Fan's Blog), reaching over 80,000 founders, scientists, investors and policy-makers.
At Capital O, he builds China's pioneering Frontier Research Organization (FRO), leading a multidisciplinary team that invests in foundational infrastructure for AI-powered science, especially in life sciences. Core to this effort are initiatives like the "Researchers-In-Residence" and "AI Science Launchpad" programs, designed to identify and co-create with scientific talent from the earliest stages.
His newsletter serves as a critical node in the Chinese tech ecosystem, providing "outlier thinking and edge ideas" on the intersection of AI, science, finance, and media. His career bridges the U.S. and China, having previously founded a shared-economy company and a fungal synbio startup, and he was among the first to introduce U.S. synthetic biology frontiers to China. He also runs the Chinese edition of Asimov Press in his spare time. Areas of Expertise: Automated Scientific Discovery Systems ；Applied Open & Citizen Science；Novel Venture Capital and Research Models
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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