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SynBioBeta Speaker

Frank Poelwijk

Generate:Biomedicines

VP, Head of Prototyping Lab

Frank J. Poelwijk is Vice President and Head of the Prototyping Lab at Generate:Biomedicines, where he is responsible for the development of experimental platforms and data-generation capabilities at scale. Trained as a physicist, he works at the intersection of technology and biology, with a focus on high-throughput, information-rich experimentation.Generate is a clinical-stage generative biology company developing new protein therapeutics by combining computational innovation with scalable biological experimentation. Its platform is designed to generate therapeutically relevant data and help create molecular solutions for challenges beyond the reach of traditional approaches.Before joining Generate, Frank held research roles at Dana-Farber Cancer Institute, the Wyss Institute, and UT Southwestern Medical Center, where he studied fitness landscapes, epistasis, and data-driven protein design, contributing to methods that link sequence variation and directed evolution to protein structure and function.

Sessions Featuring

Frank

This Year

TBD

Session lineup still growing

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Fireside Chat

12:00 AM

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8:30 AM

Human Health

From Cells to Patients: Solving the Scale Mismatch in Virtual Biology

Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?

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Speaker Coming Soon

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