
SynBioBeta Speaker
Riccardo LoCascio
Novonesis
Partnering - Precision Proteins
Riccardo LoCascio is the Head of Partnering for Precision Proteins at Novonesis, with more than 15 years of experience in precision fermentation across global corporations (Novonesis, DuPont) and biotech start ups (Evolva, Arcadia Biosciences). He has structured and executed more than $1B in value creating strategic partnerships—from joint development agreements and minority investments to major manufacturing and commercialization deals—including Novozymes’ landmark $300M investment in the Blair, Nebraska precision fermentation facility.Riccardo has played a central role in shaping the Novonesis Precision Proteins portfolio, evaluating new programs and investments, and launching multiple bio based ingredients, including SONOVA™ GLA, GoodWheat™, and Veri Te™ Resveratrol. He holds a PhD in Microbiology from UC Davis, where he conducted pioneering research on Human Milk Oligosaccharides and the infant gut microbiome.
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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