SynBioBeta Speaker
Daniel Dunkelmann
Consultant
Constructive Bio
YEAR
25
May 2025, SynBioBeta
Speaker
Daniel Dunkelmann is a consultant for Constructive Bio and a Branco Weiss Fellow at the Max Planck Institute of Molecular Plant Physiology in Potsdam-Golm. Previously, he was a Junior Research Fellow at Magdalene College, Cambridge, and completed his PhD in Jason Chin’s group at the Laboratory of Molecular Biology, Cambridge.
SynBioBeta 2025 - Keynote
From Deadlock to Discovery: Expanding Cellular Translation’s Chemical Repertoire
The genetic code has been reprogrammed to encode hundreds of non-canonical amino acids, yet its expansion beyond α-L-amino acids remained constrained for over two decades by an evolutionary deadlock: synthetases cannot be evolved for poor ribosomal substrates, and ribosomes cannot polymerize monomers that synthetases cannot acylate tRNAs with. This deadlock has now been broken with tRNA display, a rapid, scalable directed evolution platform that enables synthetase engineering to acylate tRNAs with diverse non-canonical monomers, independent of ribosomal translation. Join this session for an in-depth examination of this technology's capabilities. The session will trace tRNA's journey from conception to tech transfer and establish tRNA display as the innovation engine for next-generation therapeutics.
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Free cancelation through 2 weeks before the event, if you book before October 31st.
Conference Pass
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Access to all 120+ Sessions
Attendee Directory
Networking Reception
1:1 Partnering App
1:1 Meeting Space
Meals & Refreshments
Post Event Video Access
Before Midnight Fri, Oct 31
Regular Rate
$1,995
Purchase Pass
Purchase Pass
Free cancelation through 2 weeks before the event, if you book before October 31st.
Startup, Academic, Non-Profit or student? Join Our Next Gen Program.
Expo Pass
$495
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Access to Main Stage Streaming Content
Event App Access
Exhibit Hall Cocktail Hours
New Attendee & Welcome Reception
Purchase Pass
Purchase Pass
Free cancelation through 2 weeks before the event, if you book before October 31st.
Premium Pass
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VIP Dinner
VIP Reception
Concierge Intros
Conference Content
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2026
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