As humanity stands on the precipice of expanding its habitat beyond terrestrial confines, the role of synthetic biology in facilitating such extraterrestrial existence becomes increasingly paramount. Venturing into the vast expanse of space necessitates innovative solutions for air regeneration, aqueous purification, alimentary production, self-repairing habitats, medical sustenance, and even genetic data storage. With its transformative capabilities, synthetic biology emerges as the linchpin to ensure prolonged human subsistence in such challenging celestial environments.