SynBioBeta Speaker
Anastasia Shindyapina
Retro Biosciences
Team Lead
Anastasia received her PhD from Lomonosov Moscow State University, focusing on both molecular biology and bioinformatics. She later worked in Vadim Gladyshev’s group at Harvard Medical School, where she studied the mechanisms of immune system aging and identified interventions extending lifespan in mice. She joined Retro Biosciences with the goal of translating longevity therapies from preclinical models to patients.At Retro, her and her team develops stem cell therapies aimed at improving immune function in elderly patients with chronic and acute hematological conditions. Their approach produces young-like hematopoietic stem cells that have potential to reconstruct the entire human immune system and can be generated from patient’s own cells.
SynBioBeta 2026 Tickets are Live
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Anastasia
This Year
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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