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SynBioBeta Speaker

Jonathan Weinstein

Scala Biodesign

Prin. Scientist, Protein Design Alg. & AI

Jonathan Weinstein is a Principal Scientist for Protein Design Algorithms & AI at Scala Biodesign, where he contributes to the development of ScalaOS, a computational platform for engineering enzymes with improved stability, expression, and activity across varied industrial conditions, including cell-free manufacturing systems. His work focuses on algorithm development for protein design, with an emphasis on translating computational methods into enzymes that perform reliably at scale.Jonathan completed his PhD in computational protein design at the Weizmann Institute of Science in the laboratory of Sarel Fleishman, one of the field’s pioneering groups in native protein design and structure-based computational methods. His research philosophy centers on rigorous, structure-informed algorithm development applied directly to the demands of industrial enzyme deployment.

Sessions Featuring

Jonathan

This Year

Breakout Session

3:30 PM

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4:15 PM

Planetary Health

Biology Without Cells: The Rise of Cell-Free Biomanufacturing

Cell-free systems are redefining what’s possible in bioproduction. By bypassing the complexity of living cells, innovators can run enzyme cascades, prototype metabolic pathways, and produce high-value molecules with unmatched speed, precision, and purity. This new class of systems—from freeze-dried reactions to continuous cell-free reactors—enables rapid iteration, on-demand production, and scalable biochemistry without the need for fermentation tanks or long development cycles.

Breakout Session

3:30 PM

-

4:15 PM

Planetary Health

Biology Without Cells: The Rise of Cell-Free Biomanufacturing

Cell-free systems are redefining what’s possible in bioproduction. By bypassing the complexity of living cells, innovators can run enzyme cascades, prototype metabolic pathways, and produce high-value molecules with unmatched speed, precision, and purity. This new class of systems—from freeze-dried reactions to continuous cell-free reactors—enables rapid iteration, on-demand production, and scalable biochemistry without the need for fermentation tanks or long development cycles.

TBD

Session lineup still growing

Featuring

Speaker Coming Soon

Fireside Chat

12:00 AM

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8:30 AM

Human Health

From Cells to Patients: Solving the Scale Mismatch in Virtual Biology

Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?

Featuring

Speaker Coming Soon

Previous Speakers Include