SynBioBeta Speaker
Jonathan Weinstein
Scala Biodesign
Prin. Scientist, Protein Design Alg. & AI
Jonathan Weinstein is a Principal Scientist for Protein Design Algorithms & AI at Scala Biodesign, where he contributes to the development of ScalaOS, a computational platform for engineering enzymes with improved stability, expression, and activity across varied industrial conditions, including cell-free manufacturing systems. His work focuses on algorithm development for protein design, with an emphasis on translating computational methods into enzymes that perform reliably at scale.Jonathan completed his PhD in computational protein design at the Weizmann Institute of Science in the laboratory of Sarel Fleishman, one of the field’s pioneering groups in native protein design and structure-based computational methods. His research philosophy centers on rigorous, structure-informed algorithm development applied directly to the demands of industrial enzyme deployment.
SynBioBeta 2026 Tickets are Live
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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