
SynBioBeta Speaker
Nicolas Castellazzi
Cauldron Ferm
Chief-of-Staff
Nicolas Castellazzi is Chief of Staff at Cauldron. Nicolas brings expertise in the development and implementation of organisational strategies. Most recently, he worked at Bain & Company, leading teams of management consultants to develop business strategies, improve commercial and operational performance, and drive large transformation programs for clients. Prior to Bain, Nicolas worked in the Public Health sector with the Clinton Health Access Initiative, and in Investment Banking with UBS. Nicolas holds a Master of Science in Financial Engineering from Columbia University and a Master of Science in Applied Mathematics from CentraleSupélec.
SynBioBeta 2026 Tickets are Live
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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