SynBioBeta Speaker
Alexandra Brocato
Beakr
CEO & Cofounder
Ali Brocato is the co-founder and CEO of Beakr, an AI platform that learns how life sciences teams actually work and turns that into executable knowledge - making experimentation computable, reusable, and compounding. She completed a combined BS/MS in Biomedical Engineering at Yale in three and a half years, building two companies along the way: Simplex Sciences, now the largest supplier of ssDNA ladders to academic and industry labs, and ADVANCE, an AI-powered nurse-patient communication platform with Yale New Haven Health. She published her first research at 17 during a study at the Harvard Stem Cell Institute. Most recently before Beakr, Ali was a growth investor at General Atlantic evaluating software and healthtech companies - giving her a rare vantage point as a founder who has built, published, and invested across the life sciences stack.
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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