SynBioBeta Speaker
Ali Madani
Profluent
CEO
Ali Madani is the founder and CEO of Profluent, an AI company developing large language models (LLMs) to design proteins from scratch. Trained as a machine learning researcher, Ali has a PhD from UC Berkeley and led the ProGen project at Salesforce AI Research, the first demonstration that LLMs can generate functional proteins. He founded Profluent in 2022; the company has since raised $150M from investors including Altimeter, Jeff Bezos, Spark, Insight, and Air Street Capital and counts the world's leading pharma, agriculture, and life sciences companies as partners. Ali's research has been published in Nature, Nature Biotech, NeurIPS, ICLR and has been covered in the NYTimes, WSJ, Fortune, TechCrunch, Forbes, BBC, Endpoints, and Axios.
SynBioBeta 2026 Tickets are Live
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Ali
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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