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SynBioBeta Speaker

Jean Hebert

ARPA-H

PM, Health Science Futures

Dr. Jean Hebert joined ARPA-H in August 2024 from the Albert Einstein College of Medicine where he served as a professor of genetics and neuroscience. Hebert is the founder of BE Therapeutics, a company focused on reversing age-related damage to brain tissue. His laboratory research focuses on stem cell transplantation, plasticity, neurodegeneration, and cortical health. In addition to his academic publications, Hebert is also the author of Replacing Aging, a book on regenerative medicine and the types of cellular damage accumulated in aging tissue.Since childhood, Hebert has been interested in understanding how our bodies work and how to repair them. He has a doctorate in genetics from the University of California San Francisco and completed postdoctoral research at Stanford University studying the development of neurons that make up the neocortex.

Sessions Featuring

Jean

This Year

12:00 AM

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12:00 AM

Reversing Brain Damage: Can Programmable Biology Heal the Mind?

What if brain damage—from strokes, neurodegeneration, or even aging itself—could be reversed? ARPA-H is launching an ambitious effort to make this vision real, catalyzing technologies that repair neural circuits, restore lost tissue, and recover cognition. In this session, delivered by ARPA-H Program Manager Jean Hebert (solo), participants will dive into the role of programmable biology in healing the brain. Could engineered cells rebuild damaged regions? Could synthetic gene circuits guide regeneration? Could AI-designed therapies restore function after injury or decline? This talk will highlight high-risk, high-reward opportunities and outline a bold vision for the future of neurorepair powered by programmable biology.

12:00 AM

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12:00 AM

Reversing Brain Damage: Can Programmable Biology Heal the Mind?

What if brain damage—from strokes, neurodegeneration, or even aging itself—could be reversed? ARPA-H is launching an ambitious effort to make this vision real, catalyzing technologies that repair neural circuits, restore lost tissue, and recover cognition. In this session, delivered by ARPA-H Program Manager Jean Hebert (solo), participants will dive into the role of programmable biology in healing the brain. Could engineered cells rebuild damaged regions? Could synthetic gene circuits guide regeneration? Could AI-designed therapies restore function after injury or decline? This talk will highlight high-risk, high-reward opportunities and outline a bold vision for the future of neurorepair powered by programmable biology.

TBD

Session lineup still growing

Featuring

Speaker Coming Soon

Fireside Chat

12:00 AM

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8:30 AM

Human Health

From Cells to Patients: Solving the Scale Mismatch in Virtual Biology

Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?

Featuring

Speaker Coming Soon

Previous Speakers Include