SynBioBeta Speaker
Orly Savion
Alagene
CEO
Dr. Orly Savion is the CEO of Alagene, a synthetic biology biofoundry and CRO enabling the transition from early-stage discovery to scalable biomanufacturing. A recognized leader in Israel’s synthetic biology and industrial biotech ecosystem, she brings a multidisciplinary background spanning molecular biology, technology transfer, venture capital, and entrepreneurship. Orly leads international collaborations ranging from global corporations to academia and startups and is actively involved in innovation programs and industry consortia. Her work across biotech and biomanufacturing focuses on translating biological innovation into scalable, economically viable processes with real-world industrial impact.
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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