SynBioBeta Speaker
Viola Folli
D-Tails Srl SB
Co-Founder & CSO
Viola Folli, PhD, is a physicist and Chief Scientific Officer at D-Tails Research, where she leads the development of next-generation biosensors and synthetic olfaction systems for non-invasive cancer diagnostics. She coordinates ULYSSES, a Horizon Europe Pathfinder Open project bringing together leading European universities and cancer centers to develop GPCR-based yeast biosensors capable of detecting cancer-associated volatile compounds in urine.Her research sits at the intersection of synthetic biology, receptor engineering, microfluidics, and AI-driven signal analysis. With a background in nonlinear optics and neurobiology, she previously developed an integrated C. elegans platform combining calcium imaging, behavioral mapping, and controlled sensory stimulation to study olfactory circuits.Viola is the inventor of multiple patents in cancer biosensing and lab-on-chip systems and the author of numerous peer-reviewed publications. Her work focuses on building biological sensing platforms that enable scalable, non-invasive early cancer detection.
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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