SynBioBeta Speaker
Le Cong
Assistant Professor
Broad Institute
May 2026, SynBioBeta
Speaker
Dr. Cong's group is developing technology for large-scale genome editing and gene insertion for gene&cell therapy, integrating advance from metagenomics, computational biology, and high-throughput engineering. In parallel, the group also leverages these gene-editing tools for single-cell functional screening, to probe the molecular mechanisms of innate immunity in cancer and neuro-immune diseases. To accelerate these efforts, Dr. Cong's team integrates AI and machine learning into genome technologies, to design and evolve gene-editing proteins and RNAs in silico, significantly enhancing the efficiency and capabilities of these therapeutic molecules.
Dr. Cong's work has led to one of the first CRISPR/Cas9 gene-editing tools for in vivo gene therapy. More recently, his group invented tools for cleavage-free large gene insertion with novel recombination proteins (SSAP editor), and developed machine-learning optimized single-cell methods (DAISY) for studying cancer and immune diseases. Dr. Cong is a recipient of the NHGRI Genomic Innovator Award, Baxter Foundation Faculty Scholar, Genetic Engineering and Biotechnology News (GEN) Top 10 Under 40, Clinical OMICs Pioneers Under 40, and Clarivate Web of Science Highly Cited Researcher.
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