SynBioBeta Speaker
Rodrigo Ledesma-Amaro
Imperial College London
Professor & Director
Rodrigo Ledesma-Amaro is a Professor at Imperial College London, where he leads a research group working on Engineering Biology and sustainability. He is the director of the Bezos Centre for Sustainable Proteins and the Microbial Food Hub. His research focuses on the use of microorganisms to convert renewable feedstocks into valuable products (such as food ingredients). He has published over 200 articles, most on topics related to microbial bioproduction (precision, biomass and traditional fermentation).Rodrigo obtained his PhD at the University of Salamanca (Spain). Before joining Imperial, he carried out his postdoctoral research at the National Research Institute for Agriculture, Food and the Environment (INRAE, France). He has been a visiting researcher at Chalmers University of Technology (Sweden) and AIST (Japan).
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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