SynBioBeta Speaker
David Welch
Synthesis Capital
CSO and Co-Founder
David is Chief Scientific Officer and Co-Founder at Synthesis Capital, an investment manager created to transform our food system through food technology. At Synthesis, David combines his background in plant biology, cell therapy, and alternative proteins to identify exceptional start-ups working at the intersection of food technology, biology, and chemistry and support Synthesis portfolio companies with their technical and scale-up challenges. Prior to Synthesis, David was Director of Science and Technology at GFI where he helped start-ups, investors, corporations, and universities accelerate the development, scale-up, and commercialization of alternative protein technology. David previously served in commercial and technical roles within the life science industry at Thermo Fisher Scientific, Qiagen, Meso Scale Discovery, and 3M, which included the development and commercialization of cell lines, scaffolds, cell culture media, and immunoassays for cell therapy and pharmaceutical applications. David earned a B.Sc. in biology from the University of California at Berkeley and a Ph.D. in plant developmental cell biology from Utrecht University.
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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