SynBioBeta Speaker
Sierra Lore
Buck Institute
Doctoral Student
Sierra Lore is a PhD candidate in the Cellular and Genetic Medicine graduate program within the Faculty of Health and Medical Sciences at the University of Copenhagen and the Buck Institute for Research on Aging. She earned a Bachelor of Science in Bioengineering from Stanford University. Now, co-advised by Morten Scheibye-Knudsen at the University of Copenhagen and Eric Verdin at the Buck Institute, her work investigates the accumulation of somatic mutations across development and aging.
Lore has also developed a growing interest in replacement-based approaches to aging. She first explored this area in a Nature Aging review paper, “Replacement as an Aging Intervention,” which surveys emerging opportunities and challenges in organ- and tissue-level replacement strategies. Building on this work, she later organized and led the first-ever Replacement in Aging session at the Aging Research and Drug Discovery conference, convening researchers from multiple disciplines to advance dialogue in this emerging subfield of aging.
SynBioBeta 2026 Tickets are Live
Confirmed Speakers
Sessions Featuring
Sierra
This Year
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Human Health
Reconstructing the Body: Can Biological Replacement Reverse Aging?
Despite major advances in the biology of aging, there are still no interventions that clearly slow or reverse aging in humans. In contrast, modern medicine already depends on replacement to restore lost function, from artificial joints and cardiac devices to organ transplants and stem cell therapies. This session examines how a similar framework could be applied to aging: rather than repairing deteriorated cells and tissues, scientists and companies are exploring ways to replace them with newly generated, biologically young equivalents. The discussion will highlight emerging capabilities in engineered cell sources, scalable tissue fabrication, and programmable biology (instead of "integration") strategies that are redefining what can be rebuilt and replaced. New approaches are beginning to address long-standing challenges such as age-related signaling environments, vascularization, and even circuit compatibility in parts of the brain. Together, these advances point toward a future where rejuvenation is achieved through deliberate biological reconstruction. The session asks: How far can replacement take us, and could rebuilding youthful parts become a central path to extending healthy lifespan?
Purchase Pass
Featuring
Sierra Lore
Buck Institute
Doctoral Student
Researcher of somatic mutation in aging (immune genome instability)
Jean Hebert
ARPA-H
Program Manager
Leader in Aging Research (ARPA-H) , author of Replacing Aging
Eric Bennett
Frontier Bio
CEO
Bioprinting pioneer building lab-grown human tissues and organs.
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Human Health
Reconstructing the Body: Can Biological Replacement Reverse Aging?
Despite major advances in the biology of aging, there are still no interventions that clearly slow or reverse aging in humans. In contrast, modern medicine already depends on replacement to restore lost function, from artificial joints and cardiac devices to organ transplants and stem cell therapies. This session examines how a similar framework could be applied to aging: rather than repairing deteriorated cells and tissues, scientists and companies are exploring ways to replace them with newly generated, biologically young equivalents. The discussion will highlight emerging capabilities in engineered cell sources, scalable tissue fabrication, and programmable biology (instead of "integration") strategies that are redefining what can be rebuilt and replaced. New approaches are beginning to address long-standing challenges such as age-related signaling environments, vascularization, and even circuit compatibility in parts of the brain. Together, these advances point toward a future where rejuvenation is achieved through deliberate biological reconstruction. The session asks: How far can replacement take us, and could rebuilding youthful parts become a central path to extending healthy lifespan?
Purchase Pass
Featuring
Sierra Lore
Buck Institute
Doctoral Student
Researcher of somatic mutation in aging (immune genome instability)
Jean Hebert
ARPA-H
Program Manager
Leader in Aging Research (ARPA-H) , author of Replacing Aging
Eric Bennett
Frontier Bio
CEO
Bioprinting pioneer building lab-grown human tissues and organs.
Session lineup still growing
Purchase Pass
Featuring
Speaker Coming Soon
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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Featuring
Speaker Coming Soon
