SynBioBeta Speaker
Fabio Boniolo
Polyphron
CSO & Co-founder
Fabio Boniolo is the co-founder and CSO of Polyphron, where he leads the development of an autonomous human tissue foundry. By leveraging high-throughput data to create action-conditioned biological movies, Polyphron provides a physical validation layer and training substrate for generative biology, focusing on tissue constructs and replacement therapies. Boniolo’s research career is defined by its deep technical diversity, spanning tissue engineerig, bioprocessing and biomanufacturing, and translational cancer research. He completed his doctoral studies at the Technical University of Munich (TUM). He subsequently held a postdoctoral fellowship at the Dana-Farber Cancer Institute, Harvard Medical School, and the Broad Institute of MIT and Harvard.
SynBioBeta 2026 Tickets are Live
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Fabio
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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