SynBioBeta Speaker
Johnny Yu
Tahoe Therapeutics
CSO & Co-founder
Johnny Yu is a Co-founder and the Chief Scientific Officer at Vevo Therapeutics. He's focused on scaling frontier sized datasets to power virtual cell models, such as the Tahoe100M dataset. His work sits at the intersection of large-scale single-cell data generation initiatives for drug development across multiple disease indications. He trained at UCSF with Dr. Hani Goodarzi and Dr. Kevan Shokat and holds a PhD from UCSF.
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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