SynBioBeta Speaker
Gleb Kuznetsov
Manifold Bio
Co-founder & CEO
Gleb Kuznetsov is Co-Founder and CEO of Manifold Bio, a company combining AI protein design with generation of biological data at massive scale and physiological relevance to build organism-scale models of biology for design of therapeutics. He founded Manifold Bio after completing his PhD in the Harvard Biophysics program in the lab of George Church, where he developed new approaches for protein measurement and design by combining high-throughput biology, DNA sequencing, DNA synthesis, and machine learning technologies.
SynBioBeta 2026 Tickets are Live
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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