SynBioBeta Speaker
Michael Clear
Schmidt Sciences
Program Scientist
Michael Clear is a Program Scientist at Schmidt Sciences, where he supports the Biosciences Center’s mission to advance our understanding of biology and facilitate the transition of biological innovations into the real world for public benefit.Prior to joining Schmidt Sciences, Michael was a postdoctoral researcher in bioinformatics at Brookhaven National Laboratory, investigating how environmental factors and microbial interactions influence bioenergy crops. During his tenure as a NASA Space Grant Graduate Fellow, he utilized synthetic lichens to study microbial symbioses through dual-transcriptomics. His interest in complex microbial systems and bioproduction was sparked at Algenol, an algal biofuel company, where he managed bioreactors and modeled the microbial ecology of production systems.
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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