
SynBioBeta Speaker
Nick Ohler
Oobli
COO
Dr. Ohler received his Ph.D. in Chemical Engineering from U.C. Berkeley and is a Professional Engineer in the State of California. He has spent the last 20 years working in chemical and biochemical process development and scaleup, focusing primarily on development of new fermentation-based products. He has led development and scaleup efforts for Amyris, Bio Architecture Lab, Evolva, Lygos, and currently Oobli, developing production technology for a broad range of commodity and high-value bioproducts. He has participated and led design and startup efforts for several pilot plants and commercial-scale operations, and has worked with a wide range of contract manufacturing sites while commercializing new bioproducts. Some of those bioproducts crossed the valley of death and are on market; and some were not destined to cross that valley. Dr. Ohler endeavors to use his experience to shepherd winning products across the valley and into commercialization with speed.
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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