About
The triad of reading, writing, and editing DNA forms the foundational bedrock of synthetic biology. With burgeoning insights into DNA and advancements in its synthesis, our comprehension and mastery over technologies such as CRISPR, cell-free manufacturing, protein design, and molecular data storage have intensified. This engineering vision, once nascent, has now metamorphosed into tangible applications, facilitating the remediation of diseases, sustainable chemical production, molecular data preservation, and the synthesis of unique proteins absent in the natural realm. Such advancements inevitably prompt contemplation on the subsequent innovations birthed from the intricate manipulation of DNA.
Speakers
Agenda
Agenda
Monday
May 05
Tuesday
May 06
Unlocking Difficult-to-Engineer Bacteria with a Novel Alternative to CRISPR
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Many bacteria remain genetically intractable due to poor DNA uptake and toxicity issues associated with genome editing systems like CRISPR-Cas. Even when DNA is delivered, these tools often yield mixed populations, requiring laborious screening to isolate true mutants. We've developed a new, programmable system that enables efficient genome editing in challenging species by avoiding these common pitfalls. Originally designed for bacteria, it is now being developed for use in yeast and mammalian cells, offering broad potential across biological systems. This approach opens new frontiers in synthetic biology by making previously inaccessible organisms editable with speed and precision.
Pushing Scientific Possibilities and Traceability of Pristine DNA Molecules Through Algorithm-Driven DNA Assembly
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Inadequate DNA synthesis technologies are stalling scientific advancements and cannot meet the increasing demand for high-complexity, sequence-perfect molecules. Now, algorithm-driven technology is redefining scientific possibility by delivering pristine synthetic DNA molecules towards transformative solutions for the health of people and the planet. By combining intelligent algorithms, proprietary enzymatic assembly, adaptive automation, and end-to-end traceability from sequence to molecule, we can overcome the inefficiencies of traditional methods to produce highly accurate, long, and complex DNA ready for immediate use. These solutions are now commercially available, enabling researchers to unlock innovations in advanced therapeutics, vaccines, synthetic biology, and accelerate progress across the industry.
Pushing Boundaries: How Reliable DNA Synthesis is Accelerating Innovation in Cell and Gene Therapy
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Join leading scientists as they share how increased reliability in DNA synthesis services is transforming the way they work—empowering them to confidently expand their design space, accelerate project timelines, and drive innovation in vaccine development and cell and gene therapies. Scientists will talk about their experiences with vector onboarding, synthesis of long and complex sequences, and chromosomal and genome engineering.
Empowering Breakthroughs: How Synthetic DNA is Redefining Scientific Possibilities
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Commercial solutions providing synthetic DNA molecules have overcome some of the most challenging manufacturing hurdles, now providing molecules of varying and exceeding length, complexity, and accuracy. These advancements are enabling new possibilities and unlocking vast potential for a range of applications. In this interactive panel, we will bring together leading experts to discuss latest market advancements, innovative approaches utilizing synthetic DNA, and the transformative potential of these solutions.Join us for this discussion as we explore the potential of synthetic DNA and how it can unlock innovations for better health of people and planet.
Wednesday
May 07
Revolutionizing the Customer Experience Through Seamless Access to Synthetic DNA
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What happens in synthetic biology when a DNA synthesis company actually delivers what scientists really want? Discover how a next-generation platform is redefining DNA synthesis to meet the real needs of today’s scientists. By combining cutting-edge synthesis technology with a highly collaborative service model, advanced platforms are helping researchers move faster, access hard-to-get sequences, and expand their design space like never before. Join this talk to learn how to push the boundaries of what's possible, unlock new designs, and accelerate your next breakthrough.
Reading and Writing: How Far, How Fast, & When?
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This session will examine the frontiers of genomic sequencing and synthesis, providing a critical assessment of the present capabilities and charting likely trajectories for future progress. Participants will highlight the latest advances in instrumentation, informatics, and automation that are pushing beyond conventional limits, while also considering emerging technologies poised to reshape the landscape of DNA reading and writing. By focusing on accuracy, throughput, and scalability, this discussion will illuminate the fundamental shifts now taking place and the new horizons they open for biological research and innovation.
Thursday
May 08
Building the Future of DNA Supply with 10x Faster, Cleaner, and Scalable Gene Synthesis
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New innovations are redefining how high-quality DNA is manufactured — delivering complex, high-accuracy genes in less than 48 hours through a fully enzymatic, end-to-end workflow. Meet the new platform combining pristine single-stranded DNA synthesis, ultra-long high-fidelity oligos, automated gene assembly, and bacteria-free processes. This technology enables access to sequences traditionally considered too complex or too slow to produce. Join this talk to gain insights into key performance benchmarks, including high-fidelity synthesis of multi-kilobase genes. Designed to scale from discovery to future GMP-grade output, this platform sets a new standard for precision therapeutics, mRNA vaccines, cell and gene therapies, and advanced research programs.
Reprogramming the genetic code: Deep genetic rewiring for next-gen biotherapeutics
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Using just 20 chemical building blocks, nature’s protein-making machinery creates remarkable diversity, including therapeutics like antibodies and peptide-based drugs - yet it explores only a small fraction of the possible chemical space. Constructive Bio rewrites the genetic information of cells and rewires how this information is interpreted, enabling the creation of transformative, next-generation biotherapeutics with unprecedented properties and functions. By expanding biology’s chemical repertoire, Constructive Bio turns cells into programmable biofactories for the discovery and manufacturing of exotic biomolecules that were previously impossible.
Deconstructing Cellular Diversity: Single-Cell Sequencing for Drug Discovery and Synthetic Biology
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This session will highlight how single-cell sequencing technologies are transforming our ability to identify novel therapeutic targets, optimize engineered cell lines, and accelerate the drug discovery pipeline. By dissecting cellular heterogeneity at unprecedented resolution, these approaches are revealing intricate gene-expression patterns and pathway dynamics that guide the design of synthetic biological systems with greater precision. From refining the selection of promising drug candidates to informing the rational engineering of cell-based models, the discussion will explore how single-cell insights are redefining the frontiers of synthetic biology and unlocking new opportunities for innovative drug discovery.
