The future of medicine will be defined by bold bets: ambitious, high-risk ideas that traditional funding rarely supports but that could fundamentally transform human health. In this conversation, Alicia Jackson, Director of the Advanced Research Projects Agency for Health (ARPA-H), will share how the agency is tackling some of healthcare’s biggest challenges, drawing on a model inspired by Defense Advanced Research Projects Agency (DARPA) to accelerate breakthroughs in areas like universal immunity, AI-driven medicine, aging, and women’s health. With experience spanning government, startups, and frontier biotech (including leadership at DARPA’s Biological Technologies Office and founding Evernow) Dr. Jackson now leads a national effort to push the boundaries of what’s possible in medicine and unlock opportunities to radically improve human health.