SynBioBeta Speaker
Pardis Sabeti
Harvard
Professor
Pardis Sabeti is a professor at Harvard University and a core institute member of the Broad Institute. Her lab has pioneered technologies for detecting, tracking, and countering deadly pathogens, including Ebola, Zika, and SARS-CoV-2. They have also created some of the most powerful algorithms and molecular tools to characterize the human genome and transformative methods for gene delivery of new biomedicines.
Sabeti co-founded the African Center of Excellence for Genomic of Infectious Disease (ACEGID), training frontline scientists from 53 of 54 African countries. She has taught countless students through popular courses in genetics, statistics and outbreak science. She co-founded SHERLOCK Biosciences and serves on their foundation’s board to bring at-cost diagnostics to low and middle income countries.
Sabeti’s many honors include TIME magazine’s “Person of the Year” as one of the Ebola fighters, 100 Most Influential People, and Impact award. She is a National Academy of Medicine member and Howard Hughes Medical Institute investigator, and holds a B.S. from MIT, D.Phil. from the University of Oxford as a Rhodes Scholar, and M.D. from Harvard Medical School summa cum laude.
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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