SynBioBeta Speaker
Rongzhen Tian
Okapi Bioscience
Co-founder & CEO
Rongzhen Tian is the Co-Founder and CEO of Okapi Bioscience Ltd, which leverages, accelerates, and extends the power of evolution in living systems to make products more sustainably, and to make new classes of products. Together with scientists at the MRC Laboratory of Molecular Biology in Cambridge, he developed an orthogonal DNA replication system that now provides the scientific foundation for application and commercialization at Okapi. He is also a Principal Investigator at the Generative Biology Institute (EIT) and an Associate Professor of Biological Chemistry in the Department of Chemistry at the University of Oxford.
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Human Health
From Cells to Patients: Solving the Scale Mismatch in Virtual Biology
Drug discovery often measures biology at the cell level while interventions work at the tissue, organ, or whole-patient scale. This mismatch can make accurate cell-level predictions irrelevant in the clinic. This session dives into strategies to bridge that gap: multiscale modeling that nests single-cell dynamics within organ-level simulations, spatial transcriptomics that preserve context, and surrogate models that translate cell-level outputs into clinical biomarkers. Speakers will ask: how do we ensure virtual biology reflects not just what cells do in isolation, but how biology behaves in the real complexity of patients?
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