SynBioBeta Speaker
Matthew Osman
Co-Founder & CEO
Polyphron
May 2026, SynBioBeta
Speaker
Matthew Osman is the Co-Founder and CEO of Polyphron, a New York–based company building the world’s first personalized tissue foundry. Polyphron combines AI-guided morphogenesis models, automated wet-lab execution, and patient-derived iPSCs to manufacture functional human tissues on demand, with the goal of shifting medicine from managing chronic decline to structurally restoring and ultimately enhancing human physiology.Before Polyphron, Matthew founded Legit, an AI-powered expert network and talent platform for life sciences that matched biopharma companies with on-demand expertise and was acquired by Clora in 2021. He also founded Treat AI, an AI marketing and personalization platform whose technology for generating tailored visual content was acquired by Typeface, an enterprise generative AI company, in 2024.At Polyphron, he now leads the effort to turn developmental biology into an engineerable, model-driven process, aiming to make tissue replacement a scalable, routine pillar of healthcare.
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